With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.
62348-13-4, To a solution of CH3ONHCH3.HCl (780 mg) and acid chloride (19) in CH2Cl2 at 0 C. was added dry pyridine (1.35 ml) to afford a heterogenous mixture The solution was warmed to room temperature and stirred overnight. 1 M HCl was added to the reaction and the organic layer was separated, washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give 1 g of product (85%).
As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.
Reference£º
Patent; Schering Corporation; US2004/106794; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem