2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 3,5-dimethylisoxazole-4-carboxylic acid (0.3 mmol), oxalyl chloride (125 ? ) and catalytic amount of DMF was stirred at room temperature for 2h. After evaporating to dryness, the residual crude acid chloride was dissolved in 2 mL DCM. To the solution was added 3 (26 mg, 0.1 mmol) and DIEA (52 ??^). After stirring overnight at room temperature, the reaction mixture was worked up with aq. NaHCOs/DCM. DCM phase was washed with brine and concentrated to dryness. The residue was dissolved in 2 mL THF/MeOH/H20 (5:4: 1) and stirred with IN NaOH (100 ??) at room temperature for 2h before worked up with EA/ aq. NaHC03. Silica gel flash chromatography furnished (3,5-dimethylisoxazol-4-yl)-N-{3-fluoro-4- [l-methyl-3-(trifluoromethyl)pyrazol-5-yl]phenyl}carboxamide 92 (16 mg, yield: 41.9%, purity >95%) as a colorless gel. MS (ESI) [M+H]+ 383.1., 2510-36-3
The synthetic route of 2510-36-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CALCIMEDICA, INC.; CAO, Jianguo; WHITTEN, Jeffrey, P.; WANG, Zhijun; ROGERS, Evan; GREY, Jonathan; WO2013/59666; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem