With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.181696-35-5,4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid,as a common compound, the synthetic route is as follows.
5-methyl-3-phenyl-4- (4-sulfonic acid phenyl) isoxazole 11.7g (50mmol) dissolved in dichloromethaneOf thionyl chloride was added dropwise 9.3g (100mmol) at 0 ~ 5 reaction was stirred 40 minutes,Quenched with ice water, extracted with dichloromethane,Methylene chloride phase directly into the aqueous ammonia,The reaction temperature was raised to 20 deg.] C continued for 1 hourAfter the reaction, dichloromethane extraction,Washed, concentrated,Methanol to obtain 14.4 g of vediloxib,The yield was 91.4% and the purity was 99.54%.
181696-35-5, 181696-35-5 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid 11565904, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; Wang, Xiaoyue; (7 pag.)CN106008387; (2016); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem