With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4369-55-5,5-Amino-3-phenylisoxazole,as a common compound, the synthetic route is as follows.
Scheme 42 [0546] A mixture of tert-butyl (lS,2R)-2-(5-bromo-4-cyano-2- fluorophenylamino)cyclohexylcarbamate (165 mg, 0.400 mmol), 5-amino-3-phenylisoxazole (96 mg, 0.600 mmol), sodium phenoxide trihydrate (136 mg, 0.800 mmol), xantphos (30 mg, 0.051 mmol) and Pd2(dba)3 (30 mg, 0.032 mmol) in dioxane (2 mL) was degassed with Ar, then was heated at 170 C for 30 min by microwave. It was concentrated in vacuo. The residue was purified by HPLC to give tert-butyl (lS,2R)-2-(4-cyano-2-fluoro-5-(3- phenylisoxazol-5 -ylamino)phenylamino)cyclohexylcarbamate (40 mg) .
4369-55-5, The synthetic route of 4369-55-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; JIA, Zhaozhong, J.; SONG, Yonghong; XU, Qing; KANE, Brian; BAUER, Shawn, M.; PANDEY, Anjali; WO2012/61418; (2012); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem