With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108511-97-3,Isoxazol-4-amine,as a common compound, the synthetic route is as follows.
To a suspension of 200 mg of 6-iodoimidazo[1,2-a]pyridine-2-carboxylic acid and 266 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in 1 mL of anhydrous pyridine are added 175 mg of isoxazol-4-ylamine. The reaction mixture is stirred for 16 hours at 50 C. and then concentrated under reduced pressure. The residue is taken up in 10 mL of a mixture of chloroform and water (1/1). The solid is triturated with 3 mL of water, filtered off by suction and washed with 3 mL of water and then with 3 mL of ethyl ether, and dried to give 280 mg of 6-iodo-N-(isoxazol-4-yl)imidazo[1,2-a]pyridine-2-carboxamide in the form of a beige-coloured solid. 1H NMR spectrum (DMSO-d6, delta in ppm): 10.93 (broad s, 1H), 9.24 (broad s, 1H), 9.02 (broad s, 1H), 8.81 (broad s, 1H), 8.43 (broad s, 1H), 7.60-7.48 (m, 2H). Mass spectrum (APCI): m/z=258 [M+H]+.
108511-97-3, The synthetic route of 108511-97-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; sanofi-aventis; US2010/317686; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem