Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C4H2ClNO2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 62348-13-4
Structure-activity relationships of estrogen derivatives as aromatase inhibitors. Effects of heterocyclic substituents
Aromatase, which is responsible for the conversion of androgens to estrogens, is a potential therapeutic target for the selective lowering estrogen level in patients with estrogen-dependent breast cancer. We prepared and tested series of the pyridine- and other heterocyclic ring-containing derivatives of 2- and 4-aminoestrones, estrone, and estradiol, compounds 5, 10, 12 and 15. The isonicotinyl derivatives of 2- and 4-aminoestrone, compounds 5c and 10c, were fairly potent competitive inhibitors of aromatase (KI, 2.1±0.14 and 1.53±0.08 mum for 5c and 10c, respectively) and other compounds did not show, to a significant extent, the aromatase inhibitory activity. This result suggests that the isonicotinyl-substituted derivatives 5c and 10c would be accessible to the active site of aromatase.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem