3209-71-0, Isoxazole-3-carboxylic Acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
HOBt (4.5 g, 29.4 mmol) and EDCI (5.4 g, 28.2 mmol) were added to solution of isoxazole-3-carboxylic acid (2 1, 3 g, 26.5 mmol) and N,O-dimethylhydroxylamine (0205) hydrochloride (2.7 g, 27.7 mmol) in DMF (5 ml) and DCM (7ml). 4-methylmorpholine (3 ml, 27.3 mmol) was added, then the mixture was stirred overnight. It was extracted with ether (300 ml) and brine (100 ml), the organic layer was separated, it was washed with brine, dried over Na2S04, then filtered and the solvent was evaporated. The residue was purified by (0206) chromatography (Redisep 40 g column) eluting with 1/1 EtOAc/Hexanes yielding N-methoxy- N-methylisoxazole-3-carboxamide (2_2). LCMS (ESI) calc?d for C6H8N203 [M+H]+: 157.1, found: 157.1
3209-71-0, The synthetic route of 3209-71-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; CLAUSEN, Dane James; YU, Wensheng; KELLY, Joseph, M.; KIM, Hyunjin, M.; KOZLOWSKI, Joseph, A.; (202 pag.)WO2020/28150; (2020); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem