In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: (3-Phenyl-5-isoxazolyl)methanol, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 90924-12-2, name is (3-Phenyl-5-isoxazolyl)methanol. In an article，Which mentioned a new discovery about 90924-12-2
Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity
Despite the impressive scientific and technological advances of recent decades, no effective treatment is currently available for Chagas disease. Our research group has been studying the design and synthesis of analogues of natural lignans aiming to identify compounds with antiparasitic activity. This article reports the synthesis of 42 novel bis-heterocyclic derivatives and the structure-activity relationship study conducted based on results of biological assays against Trypanosoma cruzi amastigotes. Thirty-seven compounds were active, and eight of them had GI50 values lower than 100 muM (GI50 88.4?12.2 muM). A qualitative structure activity relationship study using three dimensional descriptors was carried out and showed a correlation between growth inhibitory potency and the presence of bulky hydrophobic groups located at rings A and D of the compounds. Compound 3-(3,4-dimethoxyphenyl)-5-((4-(4-pentylphenyl)-1H-1,2,3-triazol-1-yl)methyl)isoxazole (31) was the most active in the series (GI50 12.2 muM), showing, in vitro, low toxicity and potency similar to benznidazole (GI50 10.2 muM). These results suggest that this compound can be a promising scaffold for the design of new trypanocidal compounds.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem