With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36958-61-9,5-(Bromomethyl)-3-methylisoxazole,as a common compound, the synthetic route is as follows.
To a magnetically stirred solution of 7-(benzylthio)-4-substitued-phthalazin- 1 (2H)-one (0.40 mmol) in DMF (8 mL) at 20 C under nitrogen was added sodium hydride (0.44 mmol, 60% w/w), and the resulting mixture was agitated at ambient temperature for 1 h. 5-(Bromomethyl)-3-methyl-1 ,2-oxazole (0.44 mmol) was then added to the reaction, and the resulting mixture was agitated for 1 h at ambient temperature. Methanol (100 uL) was added to quench the reaction and the solvent was removed in vacuo to give the crude product as a residue. The residue was adsorbed onto silica and purified by automated column chromatography over silica gel eluting with a gradient of 0 to 100% EtOAc in hexane to give the desired product.This compound was prepared according to the general procedure described above for the synthesis of 7-(benzylthio)-4-substituted-2-((3-methylisoxazol-5- yl)methyl)phthalazin-1 (2H)-ones using 7-(benzylthio)-4-ethyl-phthalazin-1 (2H)-one. The desired product was isolated as an off-white solid in 90% yield.1H NMR (300MHz, DMSO-d6) delta = 8.1 1 (d, J = 1 .7 Hz, 1 H), 7.93 (d, J = 8.6 Hz, 1 H), 7.87 (dd, J = 2.0, 8.6 Hz, 1 H), 7.49 – 7.42 (m, 2H), 7.37 – 7.22 (m, 3H), 6.25 (s, 1 H), 5.76 (s, 1 H), 5.38 (s, 2H), 4.47 (s, 2H), 2.18 (s, 3H)
The synthetic route of 36958-61-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; MCGONAGLE, Alison E.; JORDAN, Allan; WASZKOWYCZ, Bohdan; HUTTON, Colin; WADDELL, Ian; HITCHIN, James R.; SMITH, Kate Mary; HAMILTON, Niall M.; (497 pag.)WO2016/92326; (2016); A1;,
Isoxazole – Wikipedia
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