With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.354795-62-3,3-Methylisoxazol-4-amine,as a common compound, the synthetic route is as follows.
Example 25H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2-To a solution of 5-(1 -methyl- 1 H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)-2- [(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 26; 44 mg, 0.10 mmol) in N,N-dimethylformamide (5 ml) was added diisopropylethylamine (0.04 ml, 0.21 mmol), 3-methyl-4-isoxazolamine (20.48 mg, 0.21 mmol), 1-hydroxy-7-azabenzotriazole (21.32 mg, 0.16 mmol) and EDC (34.0 mg, 0.18 mmol). The reaction was stirred for 18 hours and then the solvent was removed in vacuo. The residue was purified by MDAP to yield the title compound as a white solid. 43 mg.MS (electrospray): m/z, [M+H]+ = 5021 H NMR (400 MHz, DMSO-d6); 1.92 (s, 3 H), 2.80 – 3.13 (m, 3 H), 3.35 – 3.72 (m, 5 H), 3.92 (s, 3 H), 5.13 – 5.41 (m, 2 H), 7.24 (s, 1 H), 7.33 – 7.45 (m, 3 H), 7.47 – 7.62 (m, 3 H), 7.85 (d, J=3.01 Hz, 2 H), 9.16 (s, 1 H), 9.90 (s, 1 H).
The synthetic route of 354795-62-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James; WO2012/28629; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem