Let¡¯s face it, organic chemistry can seem difficult to learn, Category: Isoxazoles, Especially from a beginner¡¯s point of view. Like 88-14-2, Name is Furan-2-carboxylic acid, molecular formula is C16H13NO3, belongs to indole-building-block compound. In a document, author is Pavlik, JW, introducing its new discovery.
Synthesis of 3-phenyl-5-(trifluoromethyl)isoxazole and 5-phenyl-3-(trifluoromethyl)isoxazole
Reaction of 4,4,4-trifluoro-1-phenyl-1,3-butanedione with hydroxylamine led to the formation of 5-hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole which was dehydrated to 3-phenyl-5-(trifluoromethyl)isoxazole. This isomer can also be synthesized by reaction of 4-chloro-4-phenyl-1,1,1-trifluoro-3-buten-2-one with sodium azide. The regioisomer, 5-phenyl-3-(trifluoromethyl)isoxazole was synthesized by reaction of 1,1,1-trifluoro-4-phenylbut-3-yn-2-one with hydroxylamine and by the reaction of 3-chloro-1-phenyl-4,4,4-trifluorobut-2-en-1-one with sodium azide. Both isomers were characterized by mass and NMR spectroscopy.
If you are hungry for even more, make sure to check my other article about 88-14-2, Category: Isoxazoles.
Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem