With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.
General procedure: Nitrosyl sulfuric acid solution was prepared from concentrated sulfuric acid (1.5mL) and sodium nitrite (0.14g, 2mmol) at 70C and then cooled to 5C. This solution was added dropwise, with stirring, to 3mL of (acetic acid+propionic acid) mixture (5:1v/v) containing 2.0mmol of heterocyclic amines in an ice bath. The mixture was then stirred for 1.5h at about 0-5C. After completion of diazotization procedure, the diazonium salt solution was added dropwise to the solution of 8-chloro 4-hydroxyquinoline -2-(1H)-one (0.39g, 2.0mmol) in sodium hydroxide (0.32g, 8.0mmol) and water (6.0ml). The resulting solution was vigorously stirred at about 0-4C for 2h, while the pH of the reaction mixture was maintained 10-11 by adding 2.5% sodium hydroxide solution. The progress of the reaction was followed by TLC, using (ethyl acetate+petroleum ether) mixture (5:1 v/v) as solvent. Afterwards, the pH of reaction mixture was regulated 4-5 by means of a 10% hydrochloric acid solution. At the end of the procedure, the resulting solid was filtered, washed thoroughly with cold ethanol and dried. Recrystallization from DMF-H2O ended in pure crystals of the dye. The physical and spectral data of the purified dyes are as follows.
The synthetic route of 1072-67-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Yahyazadeh, Asieh; Yousefi, Hessamoddin; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 117; (2014); p. 696 – 701;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem