108511-97-3, Isoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 2-[(phenylmethyl)oxy]-5-(4-pyridinyl)benzoic acid (may be prepared as described in Description 79; 100 mg, 0.30 mmol), EDC (172 mg, 0.90 mmol) and HOBT (137 mg, 0.90 mmol) in dimethylformamide (3 ml) was stirred in air at room temperature for 1 h, then 4-isoxazolamine (may be prepared as described in Description 95; 100 mg, 1.189 mmol) was added in one charge. The reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with water (30 mi). The solid was filtered and dried in vacuo to obtain crude product, which was purified with Prep- HPLC (Waters, X-Bridge, 5Mm;30x100mm; A=0.05%NH3.H2O/water, B:MeCN;v=30ml/min;0-7min, 42%-54%; 7-12min, 95%; t=8.0min.) to yield the title compound as a white solid. 34 mg.’HNMR (400 MHz, DMSO-d6): 10.60 (s, 1 H), 9.27 (s, 1 H), 8.65 (s, 1 H), 8.62 (d, 2H, J=5.6), 8.08 {d, 1 H, J=2.0), 7.98 (dd, 1 H, J=2.0, 8.4), 7.74 (d, 2H, J=5.6), 7.52 (d, 2H, J=7.6), 7.42-7.33 (m, 4H), 5.36 (s, 2H).MS (electrospray); m/z [M+H]+ = 372.1
108511-97-3 Isoxazol-4-amine 13804278, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele; WO2011/38572; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem