3405-77-4, Name is 5-Methylisoxazole-3-carboxylic acid, belongs to Isoxazoles compound, is a common compound. 3405-77-4In an article, authors is Aktories, once mentioned the new application about 3405-77-4.
In hamster adipocyte ghosts, the influence of the antilipolytic agents, nicotinic acid, 5-methyl-pyrazine-2-carboxylic acid 4-oxide (acipimox) and various related compounds, was studied on adenylate cyclase and low K(m) GTPase activities. As shown for hormonal factors and nicotinic acid, the new drug, acipimox, inhibited adenylate cyclase by a GTP-dependent process, which was amplified by sodium ions; half-maximal inhibition occurred at about 10 mumol/l acipimox. For the various compounds studied, the following rank order of potency in inhibition of adenylate cyclase was obtained: nicotinic acid > 3-carboxy-5-methylpyrazole > acipimox > 3-carboxy-5-methylisoxazole; 6-hydroxynicotinic acid and beta-pyridylcarbinol had no effect up to 300 mumol/l. In the same membrane system the antilipolytic drugs increased GTP hydrolysis by stimulation of a low K(m) GTPase as shown for antilipolytic hormones. The potency order of the antilipolytic agents studied was identical for GTPase stimulation and adenylate cyclase inhibition. The data suggest that the antilipolytic drugs studied act on adipocyte adenylate cyclase via membrane-bound receptors in a hormone-like manner and that stimulation of a high affinity GTPase is involved in the mechanism of adenylate cyclase inhibition by these agents.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem