Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Fuller, Nathan O. and a compound is mentioned, 21169-71-1, Isoxazole-5-carboxylic acid, introducing its new discovery. 21169-71-1
Initial optimization of a new series of gamma-secretase modulators derived from a triterpene glycoside
The discovery of a new series of gamma-secretase modulators is disclosed. Starting from a triterpene glycoside gamma-secretase modulator that gave a very low brain-to-plasma ratio, initial SAR and optimization involved replacement of a pendant sugar with a series of morpholines. This modification led to two compounds with significantly improved central nervous system (CNS) exposure.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem