300-87-8, In an article, published in an article,authors is Buzzoni, Valentina, once mentioned the application of 300-87-8, Name is 3,5-Dimethylisoxazole,molecular formula is C5H7NO, is a conventional compound. this article was the specific content is as follows.
Aza-boronic acids as non-beta-lactam inhibitors of AmpC-beta-lactamase
With the aim of improving the ability of non-beta-lactam inhibitors to inhibit AmpC-beta-lactamase, a series of 3-aza-phenyl-boronic acid derivatives was obtained using in parallel synthesis. The molecules were tested against Escherichia coli AmpC-beta-lactamase. The best inhibitors, 3-(2-hydroxy-naphthalen-1-ylazo)-phenyl-boronic acid (12) and 3-(2,4-dihydroxy-naphthalen-1-ylazo)-phenyl-boronic acid (14), showed apparent inhibition constant values (Ki) of 0.3 and 0.45muM and increased the potency of the semi-synthetic cephalosporin antibiotic, ceftazidime, lowering its minimum inhibitory concentration (MIC) value of 50%, against Gram-negative bacteria strains, producing high levels of AmpC-beta-lactamase.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem