14678-05-8, In an article, published in an article,authors is Brown, Dearg S., once mentioned the application of 14678-05-8, Name is Isoxazol-5-amine,molecular formula is C3H4N2O, is a conventional compound. this article was the specific content is as follows.
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4- oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38alpha MAP kinase inhibitor for the treatment of inflammatory diseases
A novel, potent and selective quinazolinone series of inhibitors of p38alpha MAP kinase has been identified. Modifications designed to address the issues of poor aqueous solubility and high plasma protein binding as well as embedded aniline functionalities resulted in the identification of a clinical candidate N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin- 3(4H)-yl]benzamide (AZD6703). Optimisation was guided by understanding of the binding modes from X-ray crystallographic studies which showed a switch from DFG ‘out’ to DFG ‘in’ as the inhibitor size was reduced to improve overall properties.
If you are interested in 14678-05-8, you can contact me at any time and look forward to more communication. 14678-05-8
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem