Analyzing the synthesis route of 89102-73-8

The synthetic route of 89102-73-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89102-73-8,Isoxazol-3-ylmethanol,as a common compound, the synthetic route is as follows.,89102-73-8

A mixture of 10.0 g (100.9 mmol) isoxazol-3-ylmethanol and THF is cooled to 0C and 4.0 g (100.9 mmol) 60% NaH are added in small portions. The reaction mixture is stirred for 45 min, and then 16.4 g (84.6 mmol) 2-chloro-5-bromo-pyrimidine in DMF is added. The reaction mixture is stirred for 45 min at RT, then cooled to 0C and diluted with water. The precipitate is filtered off, washed with water and dried yielding 20.1 g 3-[(5-bromopyrimidin-2-yl)oxymethyl]isoxazole .

The synthetic route of 89102-73-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BLUM, Andreas; GODBOUT, Cedrickx; HEHN, Joerg, P.; PETERS, Stefan; (74 pag.)WO2017/194453; (2017); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem