With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21169-71-1,Isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of the above compound (35 mg, 1.0 mmol) in DMF (1 mL), isoxazole-5-carboxylic acid (23 mg, 0.20 mmol), 1-ethyl-(3-dimethylaminopropyl)carbodimide hydrochloride (38 mg 0.20 mmol), 1-hydroxy-7-azabenzotriazole (13.6 mg, 0.10 mmol), and N,N-diisopropylethylamine were added until pH=9.5. The resulting solution was stirred at room temperature for 3 hours and then 0.3 mL of water was added. Purification was achieved by preparative HPLC on a delta-pack C18 column, 300 , pore size 15 muM with 0.05% HCl acid -aqueous acetonitrile solvent systems using various linear gradients to afford the HCl salt of the title compound as a white solid that gave a proton NMR spectrum consistent with theory and a mass ion (ES+) of 442.2 for M+H+: 1H NMR (500 MHz, DMSO-d6) delta 1.61 (d, J=6.7 Hz, 3H), 2.21 (s, 3H), 5.47 (d, 1H), 6.86 (br s, 1 H), 7.36 (d, J=1.9 Hz, 1H), 7.49 (d, J=7.8 Hz, 1H), 7.55 (t, J=8.6 Hz, 1H), 7.83 (d, J=6.4 Hz, 1H), 7.85 (t, J=7.57 Hz, 1H), 8.86 (d, J=1.9 Hz, 1H), 10.54 (br s, 1H),, 21169-71-1
21169-71-1 Isoxazole-5-carboxylic acid 2060599, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; Kuduk, Scott D.; Bock, Mark G.; Feng, Dong-Mei; Wai, Jenny Miu-Chun; US2004/29920; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem