With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1750-42-1,Isoxazol-3-amine,as a common compound, the synthetic route is as follows.
To a solution of isoxazol-3-amine (313 mg, 3.729 mmol) and imidazole (761 mg, 11.19 mmol) in DCM (9 mL) at -78 C was added SO2Cl2 (503 mg, 3.729 mmol) dropwise. The mixture was warmed to room temperature and stirred for 30 min.1-[5-fluoro-2-methoxy-4-[3-(trifluoromethyl)phenyl]phenyl]- 3,4,4a,5,6,7,8,8a-octahydro-1,6-naphthyridin-2-one (315 mg, 0.7457 mmol) in DCM (1 mL) was then added. The mixture was heated at 80 C for 30 min. The reaction was quenched with water, extracted with DCM (3x). The combined organics were dried (Na2SO4), filtered and concentrated. The crude product was purified by silica flash chromatography (0-10% MeOH/DCM) to give the title compound (235 mg, 55%) as yellow oil. LCMS (ESI) m/z 569 [M+H]+., 1750-42-1
The synthetic route of 1750-42-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; MCKERRALL, Steven; SAFINA, Brian Salvatore; KOLESNIKOV, Aleksandr; ZHANG, Birong; LIU, Wenfeng; LAI, Kwong Wah; (110 pag.)WO2019/191702; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem