With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.,2510-36-3
Preparation 34 N-methoxy-N,3,5-trimethylisoxazole-4-carboxamide A/-methoxy-A/,3,5-trimethylisoxazole-4-carboxamide A solution of 3,5-dimethylisoxazole-4-carboxylic acid (15 g, 106 mmol), N,0- dimethylhydroxylamine hydrochloride (11.40 g, 1 17 mmol), HATU (44.5 g, 117 mmol) and Hunig’s Base (46.4 ml, 266 mmol) in DCM (304 ml) was stirred at rt for 2 days. Water was added and the aqueous layer was extracted with DCM (x3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and filtered, and the filtrate was evaporated in vacuo to give the crude product. The crude product was purified by silica gel chromatography eluting with 0-40% EtOAc/Hexane to give N- methoxy-N,3,5-trimethylisoxazole-4-carboxamide (19 g) as a colorless oil. ‘H NMR (500MHz, CHLOROFORM-d) delta 3.53 (s, 3H), 3.36 (s, 3H), 2.48 (s, 3H), 2.34 (s, 3H).
As the paragraph descriping shows that 2510-36-3 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WU, Yong-Jin; GUERNON, Jason M.; WO2014/98831; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem