847490-69-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.847490-69-1,4-Iodoisoxazole,as a common compound, the synthetic route is as follows.
[00460] Step 2: Synthesis of 3-(isoxazol-4-yl)benzaldehyde: To a mixture of 4- iodoisoxazole (1 g, 5.13 mmol), 3-formylphenylboric acid (923 mg, 6.15 mmol) and sodium carbonate in DME/H20/Toluene/EtOH (15 mL, 3/1/10/6, V/V) was added Pd(PPh3)4 (200 mg). The mixture was purged with N2 for 30 min and heated to 80 C for 3 h. The reaction mixture was cooled followed by a standard aqueous/EtOAc workup and purified by prep- TLC (EA : PE = 1 : 5) to give Intermediate 46 (12 mg, 1.5%).
847490-69-1 4-Iodoisoxazole 22274060, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian; WO2011/38204; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem