Brief introduction of 14678-02-5

14678-02-5, The synthetic route of 14678-02-5 has been constantly updated, and we look forward to future research findings.

14678-02-5, 5-Amino-3-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Methylisoxazol-5-amine (2.9 g) and potassium carbonate (9.8 g) were suspended in dichloromethane (100 mL) at room temperature 2-bromoacetyl bromide (6 g) was added dropwise. The mixture was allowed to stir overnight. Water (0.3 mL) was added together with a further quantity of potassium carbonate (3 g) and the reaction stirred for a further 30 minutes. The reaction mixture was poured into water (100 mL) and extracted with dichloromethane (2 x 50 mL). The combined organic extracts were dried over Magnesium Sulfate and then evaporated in vacuo. The crude product was purifed by column chromatography on silica eluting with ethyl actetate / isohsxane (50:50) to give sub-titled compound (4.8 g).1H NMR (299.946 MHz, CDCl3) delta 11.97 (s, IH)5 6.16 (s, IH), 4.09 (s, 2H), 2.19 (s, 3H).

14678-02-5, The synthetic route of 14678-02-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/59245; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem