With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5765-44-6,5-Methylisoxazole,as a common compound, the synthetic route is as follows.
5765-44-6, Example 11A Sodium 1-cyanoprop-1-en-2-olate Sodium (7.69 g, 335 mmol) is introduced in portions into 350 ml of anhydrous methanol. After the reaction mixture has been cooled to 25 C., 5-methylisoxazole (27.8 g, 335 mmol) is slowly added in portions (exothermic reaction). After the addition is complete, the mixture is stirred at RT for 4 h and then concentrated. The residue is washed with a little diethyl ether, filtered off with suction and dried under oil pump vacuum. 32.0 g (91% of theory) of the title compound are obtained. 1H-NMR (400 MHz, DMSO-d6): delta=3.18 (s, 1H), 1.51 (s, 3H).
5765-44-6 5-Methylisoxazole 79833, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2010/305052; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem