3405-77-4, 5-Methylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 5-methylisoxazole-3-carboxylic acid (284.0 mg, 2236.0 mumol) dissolved in DCM(lO.OmL) was added HATU (1020.0 mg, 2683.0 mumol) followed by DIEA(586mul, 3353 mumol). The solution was stirred at room temperature for 5 minutes. 4-amino-2-(l- methyl-lH-pyrazol-5-yl)phenol (500.00 mg, 2236 mumol) was added and the reaction mixture was stirred at 25¡ãC for 15 hours. The reaction mixture was subjected to purification by column chromatography (ethyl acetate rhexane 50:50) to afford the title compound as an off- white solid in 59.0percent yield. LCMS m/z = 333.2 (M+H), 1H NMR (400 MHz5 OMSO-d) delta ppm 2.69 (s, 3H), 3.66 (s, 3 H), 6.64 (s, 1 H), 7.00 (d, /=8.84 Hz, 1 H), 7.61 (s, 1 H), 7.64 (d, /=2.53 Hz, 1 H), 7.73 (dd, /=8.84, 2.53 Hz, 1 H), 10.04 (s, 1 H), 10.60 (s, 1 H).
3405-77-4, The synthetic route of 3405-77-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ARENA PHARMACEUTICALS, INC.; WO2007/136703; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem