With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-37-5,4-(Chloromethyl)-3,5-dimethylisoxazole,as a common compound, the synthetic route is as follows.
4-Chloromethyl-3,5-dimethyl-isoxazole (500 muL, 3.40 mmol) was added to a mixture of phthalimide (500 mg, 3.40 mmol) and K2CO3 (500 mg, 3.62 mmol) in DMF (5mL) and stirred at ambient temperature overnight. The reaction was then heated to 70 C for 5 hours and subsequently cooled and partitioned between ethyl acetate and water. The organic layer was washed several times with water and concentrated to give 1.0 g of the sub-title compound as a white solid. MS: ESI (positive): 257 (M+H)., 19788-37-5
19788-37-5 4-(Chloromethyl)-3,5-dimethylisoxazole 88246, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; ATHERSYS, INC.; WO2006/34419; (2006); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem