With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-37-5,4-(Chloromethyl)-3,5-dimethylisoxazole,as a common compound, the synthetic route is as follows.
General procedure: The corresponding alkyl halide reagent (1mmol) was added to a mixture of selenourea (1.1mmol) (compounds 1a-j) or thiourea (compounds 2a-j) in absolute ethanol (20mL). The mixture was stirred at reflux, room temperature or 0C for 0.5-6h. The product was isolated by filtration or by rotatory evaporation of the solvent under vacuum and purified by recrystallization or washing. 4.1.11 (3,5-Dimethylisoxazol-4-yl)methyl carbamimidoselenoate hydrochloride (1i); Conditions: 2.5 h at reflux. After this time, the mixture was filtered and the solvent was removed under vacuum by rotatory evaporation. The brown powder was washed with acetone (25mL). Yield: 76%; mp: 168-170C. 1H NMR (400MHz, DMSO-d6): delta 2.23 (s, 3H, C3-CH3), 2.40 (s, 3H, C5-CH3), 4.41 (s, 2H, -CH2-), 9.50ppm (bs, 4H, NH2+NH+HCl). 13C NMR (100MHz, DMSO-d6): delta 10.7 ((C5)-CH3), 11.8 ((C3)-CH3), 19.5 (-CH2-), 110.6 (C4), 160.1 (C5), 166.5 (C3), 167.7ppm (Se-C-(NH)(NH2)). IR (KBr): nu 3220-3100 (s; N-H, N-H2), 1655cm-1(s, C=N). MS (m/z (% abundance)): 228(13), 213(22), 190(24), 156(43), 110(98), 68(100), 43(100). Elemental analysis calculated (%) for C7H11N3OSe HCl: C: 31.30, H: 4.50, N: 15.64; found: C: 30.94, H: 4.59, N: 15.53.
19788-37-5, As the paragraph descriping shows that 19788-37-5 is playing an increasingly important role.
Reference£º
Article; Alcolea, Veronica; Plano, Daniel; Karelia, Deepkamal N.; Palop, Juan Antonio; Amin, Shantu; Sanmartin, Carmen; Sharma, Arun K.; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 134 – 144;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem