With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-02-5,5-Amino-3-methylisoxazole,as a common compound, the synthetic route is as follows.
General procedure: To 4-amino-3-methyl-5-styrylisoxazoles 7 [18h,20] (1.0 mmol, 0.750 g) in 0.5 mL of AcOH and 4.5 mL of water, dimedone 8 (1.0 mmol, 0.525 g) was added and the reaction mixture refluxed at 100 C for 10 min, followed by the addition of aryl glyoxal monohydrates 9 (1.0 mmol, 0.569 g) and 5-amino-3-methylisoxazole 10 (1 mmol, 0.367 g) and the reaction continued for another 50 min. After completion of the reaction (monitored by TLC), the mixture was cooled to room temperature and poured into ice-cold water. The precipitate that formed was filtered off, washed with ice cold water and the crude product was purified by recrystallization from methanol to give pure bis-isoxazolopyrroloquinolines 11.
14678-02-5, 14678-02-5 5-Amino-3-methylisoxazole 84590, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Article; Rayudu, Sri Venkateswarlu; Karmakar, Dipankar; Kumar, Pramod; Tetrahedron Letters; vol. 60; 36; (2019);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem