Liu, Yi et al. published their research in Psychiatry Research in 2022 | CAS: 144598-75-4

3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Fe(CO)5 efficiently cleaves the N–O bond of fused isoxazolo-1,4-quinones to give the corresponding imines.All the common reducing reagents failed to open the isoxazole ring.Electric Literature of C23H27FN4O3

Adjuvant electroconvulsive therapy with antipsychotics is associated with improvement in auditory mismatch negativity in schizophrenia was written by Liu, Yi;Jia, Li-na;Wu, Han;Jiang, Wei;Wang, Qian;Wang, Dan;Xiong, Yan-bing;Ren, Yan-ping;Ma, Xin;Tang, Yi-lang. And the article was included in Psychiatry Research in 2022.Electric Literature of C23H27FN4O3 This article mentions the following:

Schizophrenia is a common mental disorder characterized by pos. (psychotic) symptoms, neg. symptoms, and cognitive deficits. We found electroconvulsive therapy (ECT) treatment was associated with improvement in clin. symptoms, cognitive function, as well as auditory Mismatch negativity (MMN). The changes in MMN were associated with the improvement in cognition. MMN may be a biomarker of the effects of ECT on cognitive function in patients with SZ. To our knowledge, the effects of ECT on MMN in patients with SZ have not been reported. Therefore, the present study was set to investigate the effects of ECT on auditory MMN in patients with SZ and explore the relations between MMN, psychotic symptoms, and cognitive function before and after ECT treatment. We used the bifrontal electrode placement and all patients received 8 sessions. Our hypotheses were: (1)Compared with age-and sex-matched healthy controls, patients with SZ were worse in MMN and cognitive function; (2) ECT treatment would lead to improvement in clin. symptoms, cognitive function, and MMN amplitude; (3) There were significant correlations between the changes in MMN and changes in clin. symptoms and cognitive measurements, In the experiment, the researchers used many compounds, for example, 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4Electric Literature of C23H27FN4O3).

3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Fe(CO)5 efficiently cleaves the N–O bond of fused isoxazolo-1,4-quinones to give the corresponding imines.All the common reducing reagents failed to open the isoxazole ring.Electric Literature of C23H27FN4O3

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem