Pieroni, Marco et al. published their research in Journal of Medicinal Chemistry in 2009 | CAS: 5765-44-6

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Synthetic Route of C4H5NO

Synthesis, Biological Evaluation, and Structure-Activity Relationships for 5-[(E)-2-Arylethenyl]-3-isoxazolecarboxylic Acid Alkyl Ester Derivatives as Valuable Antitubercular Chemotypes was written by Pieroni, Marco;Lilienkampf, Annamaria;Wan, Baojie;Wang, Yuehong;Franzblau, Scott G.;Kozikowski, Alan P.. And the article was included in Journal of Medicinal Chemistry in 2009.Synthetic Route of C4H5NO This article mentions the following:

Tuberculosis (TB), mostly caused by Mycobacterium tuberculosis (Mtb), is one of the leading causes of death from infectious disease worldwide. Its coinfection with HIV and the emergence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) strains have further worsened the TB pandemic. Despite its global impact, TB is considered a neglected disease and no new anti-TB therapeutics have been introduced over the last four decades. The nonreplicating persistent form of TB (NRP-TB) is responsible for the length of the treatment and is the putative cause of treatment failure. Therefore, new anti-TB agents, which are active against both the replicating form of Mtb (R-TB) and NRP-TB, are urgently needed. The synthesis and structure-activity relationships (SAR) of a series of 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl esters e.g. I, as potent anti-TB agents are reported. Several compounds had submicromolar min. inhibitory concentrations (MIC) against R-TB and were active against NRP-TB in the low micromolar range, thus representing attractive lead compounds for the possible development of new anti-TB agents. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Synthetic Route of C4H5NO).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Synthetic Route of C4H5NO

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem