Synthesis of novel bicyclic 2-amino-4(1H)-pyridones. Reaction of lactim ethers with α-cyanoacetone dianion was written by Jiang, Jack B.;Urbanski, Maud J.. And the article was included in Tetrahedron Letters in 1985.Category: isoxazole This article mentions the following:
Lactim ethers I (X = S, bond; Z = O,S; n = 1-4), treated with C–H2COC–HCN followed by MeOH, yielded bicyclic 2-amino-4(1H)-pyridones II. The dianion was generated in situ by treating 5-methylisoxazole with LiN(CHMe2)2. In the absence of MeOH ring closure did not occur. O-, N-, And C-alkylation of II was demonstrated. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Category: isoxazole).
5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Category: isoxazole
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem