Quantification of panel of most potent antipsychotic medicines by high throughput UPLC method was written by Jebaliya, Hetal;Shah, Anamik;Karad, Sharad C.;Nakum, Shraddha;Dabhi, Batuk. And the article was included in Results in Chemistry in 2022.COA of Formula: C23H27FN4O3 This article mentions the following:
The delegated work entails the simultaneous quantification and validation of a panel of common antipsychotic compounds in dosage form using the UPLC method. The antipsychotic medications used in the study were; Amisulpride, Risperidone, Paliperidone, Ziprasidone, Aripiprazole and Lurasidone. Acquity UPLC@BEH shield RP C18 (100 mm X 2.1 mm id, 1.7 m particle size) column was used to sep. the samples with gradient elution consisting of 0.1% TFA and ACN with a PDA detector. The entire anal. took only 7 min with a 0.3 mL/min flow rate, 1 μl injection volume and a 45 °C column oven temperature The current approach provides good resolution and low solvent consumption in a short amount of time. In most Quality Control laboratories, time-consuming methods and distinct mobile phases are used for different dosage forms of pharmaceuticals, however, the proposed method saves time and money by removing the need to change mobile phases. As a result, the method can be used in QC laboratories where time-consuming methods are used with different mobile-stationary phases. Antipsychotic drug anal. is mainly utilized in QC laboratory and forensic toxicol. to monitor medication therapy or to explain the cause of intoxication in human performance and post-mortem situations. In the experiment, the researchers used many compounds, for example, 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4COA of Formula: C23H27FN4O3).
3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. Isoxazoles are commonly used as enaminoketone or β-diketone surrogate. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.COA of Formula: C23H27FN4O3
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem