Discovery of a new class of p38 kinase inhibitors was written by Dumas, J.;Sibley, R.;Riedl, B.;Monahan, M. K.;Lee, W.;Lowinger, T. B.;Redman, A. M.;Johnson, J. S.;Kingery-Wood, J.;Scott, W. J.;Smith, R. A.;Bobko, M.;Schoenleber, R.;Ranges, G. E.;Housley, T. J.;Bhargava, A.;Wilhelm, S. M.;Shrikhande, A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Category: isoxazole This article mentions the following:
The MAP kinase p38 has been implicated in cytokine signaling, and its inhibitors are potentially useful for the treatment of arthritis and osteoporosis. Novel small-mol. inhibitors of p38 kinase were derived from a combinatorial chem. effort and exhibit activity in the nanomolar range. Very steep structure-activity relationships are observed within this class. In the experiment, the researchers used many compounds, for example, 3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9Category: isoxazole).
3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. Isoxazoles are commonly used as enaminoketone or β-diketone surrogate. Fe(CO)5 efficiently cleaves the N–O bond of fused isoxazolo-1,4-quinones to give the corresponding imines.All the common reducing reagents failed to open the isoxazole ring.Category: isoxazole
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem