Synthesis and biological evaluation of novel 5,6-dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors was written by Ding, Lei;Zhang, Qing;Zhao, Kuantao;Jiao, Xiaoyu;Zhou, Ying;Fan, Weizheng;Tang, Chunlei. And the article was included in Chemical Biology & Drug Design in 2022.Recommanded Product: 3-(tert-Butyl)isoxazol-5-amine This article mentions the following:
Fms-like tyrosine kinase 3 (FLT3) is widely expressed and often mutated in acute myeloid leukemia (AML), which makes it an important target for the treatment of AML. The structure-based synthesis and biol. evaluation of 5,6-dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors have been studied in this paper. Compound I derivatives (X and Y = N, CH, CF, or CCH3 and R = isoxazole derivatives) displayed comparable inhibitory potency against FLT3-ITD and showed remarkable antiproliferative activities against MV4-11. In the experiment, the researchers used many compounds, for example, 3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9Recommanded Product: 3-(tert-Butyl)isoxazol-5-amine).
3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9) belongs to isoxazole derivatives. Isoxazole rings are found in some natural products, such as ibotenic acid and muscimol. As with isoxazolines, isoxazoles may be cleaved using low-valent titanium obtained from the Kulinkovich reaction.This procedure affords enaminoketones from 2,4-substituted isoxazoles.Recommanded Product: 3-(tert-Butyl)isoxazol-5-amine
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem