Practical synthesis of 3-amino-5-tert-butylisoxazole from 4,4-dimethyl-3-oxopentanenitrile with hydroxylamine was written by Takase, Akira;Murabayashi, Akira;Sumimoto, Shinzaburo;Ueda, Shiro;Makisumi, Yasuo. And the article was included in Heterocycles in 1991.Computed Properties of C7H12N2O This article mentions the following:
A good yield of 3-amino-5-tert-butylisoxazole (I; R = CMe3) was obtained regioselectively from a reaction of 4,4-dimethyl-3-oxopentanenitrile with hydroxylamine in aqueous solution adjusted to weakly basic, followed by treatment of the resulting 4,4-dimethyl-3-oxopentaneamidoxime with hydrochloride acid. I (R = Me2CH, Ph) were prepared in poor yields (27-38%) by the same procedure starting from 4-methyl-3-oxopentanenitrile and benzoylacetonitrile, resp. In the experiment, the researchers used many compounds, for example, 3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9Computed Properties of C7H12N2O).
3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. Isoxazoles are commonly used as enaminoketone or β-diketone surrogate. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Computed Properties of C7H12N2O
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem