Liang, Shujun published the artcileEffect of sequential celecoxib with parecoxib sodium on perioperative analgesia and joint function recovery of total hip replacement, SDS of cas: 198470-85-8, the publication is Hebei Yixue (2015), 21(11), 1869-1872, database is CAplus.
Objective: To observe and explore the analgesic effect of sequential celecoxib with parecoxib sodium during unilateral total hip arthroplasty (THR) during perioperative period, and to compare with the effect of tramadol. Methods: A total of 102 unilateral THR patients selected from 2011 to May 2014 were randomly divided into a study group (52 cases) and a control group (50 cases). In the study group, 40 mg parecoxib sodium was injected i.v. 30 min before anesthesia induction, and THR surgery was performed after routine anesthesia, analgesia pump was routinely used for analgesia for 2 days after surgery, and 40 mg parecoxib sodium was injected i.v. 3 h after surgery, 2 times/d, for consecutive days, and on the 3rd postoperative day, the celecoxib capsules were taken orally at 200 mg twice a day until discharged. In the control group, 100 mg tramadol injection was injected, and on the 3rd postoperative day, tramadol tablets were taken orally, and other analgesic regimens during the perioperative period were the same as the study group. The visual analog pain (VAS) score and passive active Harris hip score were compared in the perioperative resting state between the two groups. Adverse drug reactions were recorded during analgesia. Results: Within 24 h after operation, the number of analgesia pump compressions in the study group (10.2 ± 3.5) was significantly less than that in the control group (15.8 ± 5.5) (u = 6.108, P < 0.001). The VAS scores at 12 h, 24 h, 48 ??hours, 72 h, and 96 h in the study group were significantly lower than those in the control group (P < 0.05). The Harris hip scores at 7 and 14 days after surgery in both groups were significantly improved compared with those before surgery. The scores at 7 and 14 days after surgery in the study group were significantly higher than those in the control group (P < 0.05). The perioperative nausea, vomiting, dizziness, drowsiness, urinary retention and other adverse drug reactions in the study group were lower than those in the control group, without statistically significant difference (P > 0.05). Conclusion: Sequential celecoxib with parecoxib sodium during THR during perioperative period can significantly reduce the pain of patients, reduce the dose of opioids in the analgesia pump, and help patients to exercise hip function as soon as possible, and has low incidence of the adverse reactions compared with tramadol.
Hebei Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, SDS of cas: 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem