Li, Jun published the artcileInfluences of parecoxib sodium on pulmonary oxygenation function in patients after valve replacement under cardiopulmonary bypass, Computed Properties of 198470-85-8, the publication is Jilin Yixue (2014), 35(34), 7638-7640, database is CAplus.
The influences of parecoxib sodium on pulmonary oxygenation function in patients after valve replacement under cardiopulmonary bypass (CPB) were evaluated. Sixty-three patients suffering from valve replacement under CPB were collected and divided into three groups: the control group (group I), parecoxib sodium 20 mg group (group II) and parecoxib sodium 40 mg group (group III). The changes of end-tidal CO2 pressure (PETCO2), arterial O2 concentration (CaO2), pulmonary alveolar-arterial O2 pressure (PA-aO2), oxygenation index (OI), spontaneous breathing frequency and ventilator assisted ventilation time in these patients were observed and compared. In group I, the levels of PA-aO2 and OI after surgery were significantly increased as compared before surgery. And the levels of PA-aO2 and OI in group III were significantly lower than those in group I and group II. The most stable spontaneous breathing frequency and the lowest incidence rate of dry/moist rales were observed in group III. It indicated that parecoxib sodium had protective effects on pulmonary injury and oxygenation function improvement in patients after valve replacement under CPB.
Jilin Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Computed Properties of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem