Huang, Shuai-hao published the artcileComparison of analgesia effect of non-steroidal anti-inflammatory drugs after posterior lumbar fusion surgery, Application In Synthesis of 198470-85-8, the publication is Shiyong Yixue Zazhi (2014), 30(20), 3321-3323, database is CAplus.
The purpose of the research is to compare the analgesia effect and the safety of Flurbiprofen Axetil (FA) and Parecoxib Sodium (PS) after posterior lumbar fusion surgery. 90 Cases of patients undergoing internal fixation of lumbar spine were randomly assigned to 3 groups:those in Group A(n=30) received 100 mg of FA; those in Group B (n=30) received 40 mg of PS and those in Group C received saline. The VAS scores of 2, 6, 12, 24, 48, 72 h after operation and the dose of tramadol hydrochloride (TH) used and the side effect was recorded resp. Group A and B had significantly better analgesic effect than Group C(P<0.05). Group A and B had lower average dose of TH than Group C (P<0.05). The VAS scores in Group A was lower than that in Group B in 2 h after the surgery. The VAS scores after the surgery showed no significant difference between Group A and B in 6 , 12, 24 h after the surgery. The VAS scores in Group A was higher than that in Group B in 48, 72 h after the surgery. Both PS and FA can alleviate postoperative pain and have fewer adverse reactions.
Shiyong Yixue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Application In Synthesis of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem