Zhang, Jin-li published the artcileInfluence of preemptive analgesia with parecoxib sodium on stress reaction and inflammation reaction in elderly patients after abdominal operation, HPLC of Formula: 198470-85-8, the publication is Hainan Yixueyuan Xuebao (2014), 20(6), 854-856, database is CAplus.
Objective: To investigate the effect of preemptive analgesia with parecoxib sodium on stress reaction and inflammation reaction in elderly patients after abdominal operation. Methods: A total of 60 cases aged 60-75 years old were randomly divided into observation group and control group by half. They received i.v. injection of parecoxib sodium 40 mg (diluted with saline to 4 mL) 15 min before anesthesia in observation group. Patients in control group were injected with saline 4 mL. VAS score was measured 1 h, 6 h, 12 h, 24 h after surgery. 6 ML venous blood was extracted at 5 min before anesthesia (T0). 1 H after operation (T1), 6 h after operation (T2), 12 h after operation (T3), 24 h after operation (T4) to determine cortisol (Cor) and interleukin-6 (IL-6) concentration Result: VAS score in observation group at different time points was significantly lower than those of control group (P < 0.01); Cor and IL-6 at T1, T2, T3, T4 were significantly lower than those in the control group (P < 0.01). Conclusion: preemptive analgesia with parecoxib sodium can effectively relieve postoperative pain in elderly patients with abdominal operation. It can reduce the stress response, and inhibit the release of inflammatory mediators.
Hainan Yixueyuan Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H4FNO3, HPLC of Formula: 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem