Bi, Yan published the artcileAnalysis of influence of parecoxib sodium on recovery period after laparoscopic cholecystectomy under fast track anesthesia with remifentanil later, HPLC of Formula: 198470-85-8, the publication is Yixue Zongshu (2015), 21(10), 1890-1892, database is CAplus.
Objective To observe the influence of parecoxib sodium on the recovery period after laparoscopic cholecystectomy (LC) under fast track anesthesia with remifentanil. Methods A total of 114 cases of gallstone admitted in Shaoguan First People’s Hospital from Mar. 2013 to Feb. 2014 were divided into the control group (56 cases) and observation group (58 cases) by random number table method. Patients in both groups received LC treatment under fast track anesthesia with remifentanil, patients in the observation group received injection of 5 mL saline and parecoxib sodium mixture 20 min before anesthesia, while patients in the control group received injection of 5 mL saline. The awake and extubation time of the two groups was recorded, while changes of mean pulsating pressure (MAP), pulse oxygen saturation (SpO2), heart rate and other indicators of recovery period were observed at the time points of 5 min before extubation (T1), extubation time (T2), 5 min after extubation (T3) and 15 min after extubation (T4), besides, Ramsay sedation and VAS pain scores were recorded, incidences of restlessness, arrhythmia and other adverse reactions were observed Results MAP, heart rate of the observation group only fluctuated at T2, then leveled off; MAP, heart rate of the control group significantly fluctuated after T1, there was statistically significant difference between the two groups (P<0.05). Postoperative agitation score and VAS pain score of the observation group were (1.8±0.9) scores and (2.3±1.2) scores, significantly lower than those of the control group (3.4±1.0) scores and (4.2±1.3) scores], while Ramsay sedation score was higher than the control group [(3.5±1.1) scores vs (1.7±0.8) scores], the difference was statistically significant (P<0.01). The incidence of agitation of the observation group was lower than the control group [10.3% (6/58) vs 30.4% (17/56)], the difference was statistically significant (P<0.01). Conclusion Application of parecoxib sodium to induce the fast track anesthesia with remifentanil before LC can stable the hemodynamics, reduce postoperative pain and stress response, with fewer adverse reactions, therefore, it is worth for clin. promotion.
Yixue Zongshu published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, HPLC of Formula: 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem