He, Lijiang published the artcileEfficacy analysis of parecoxib sodium in postoperative analgesia of thoracolumbar fractures, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Fujian Yiyao Zazhi (2014), 36(4), 113-114, database is CAplus.
Objective: To observe the clin. efficacy of parecoxib sodium in thoracolumbar fracture postoperative analgesia. Methods: 52 cases of patients with posterior decompression internal fixation surgery of general anesthesia after single thoracolumbar vertebral fracture were randomly divided into group A and group B. A group was given i.v. parecoxib sodium injection 40 mg after surgery, and group B for i.m. injection tramadol 100 mg. The onset time, visual analog pain scores, and adverse reactions at each time point of two groups were compared. Results: A group had analgesic onset time (11.36 ± 5.63) min, group B had analgesic onset time (17.27 ± 8.75) min, and the difference was statistically significant (P < 0.05). At each point visual analog analgesia score of A group was lower than that of group B, and A group had better analgesic effect (P < 0.05). The group A had better incidence of adverse reactions than group B (P < 0.05). Conclusion: Parecoxib sodium can effectively alleviate the thoracolumbar fracture postoperative pain, and is appropriate medication for i.v. analgesia.
Fujian Yiyao Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem