Sukanya, S. H. published the artcileFacile TiO2 NPs catalysed synthesis of substituted-4-Hydroxy/methoxy benzylidene derivatives as potent antioxidant and anti-tubercular agents, Name: 3-Phenylisoxazol-5(2H)-one, the publication is Chemical Data Collections (2021), 100713, database is CAplus.
In this work, a facile synthesis of a series of substituted-4-hydroxy/methoxy benzylidene derivatives e.g., I via Knoevenagel condensation reaction of different active methylene compounds e.g., II with 4-hydroxy/methoxy benzaldehyde under reflux condition in aqueous EtOH using catalytic amount of TiO2 NPs was reported. The structures of all the obtained compounds were confirmed by anal. and spectroscopic methods and screened for their antioxidant and anti-tubercular activities. Antioxidant activity results revealed that, the compound I with IC50 value 105.48μg/mL showed very effective DPPH scavenging activity and compound III with IC50 value 129.72μg/mL exhibited most effective nitric oxide radical scavenging activity compared to the reference standard BHT and ascorbic acid resp. From the results of anti-TB activity, compound IV displayed a more sensitivity at 25μg/mL. Furthermore, synthesized compounds were assessed for mol. docking studies on the target enzymes Human peroxiredoxin 5 and enoyl-ACP reductase and they were emerged has an active antioxidant and anti-TB agents with least binding energy -5.8 and -8.0 kJ mol-1 resp.
Chemical Data Collections published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C44H28ClFeN4, Name: 3-Phenylisoxazol-5(2H)-one.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem