Mahran, Asma M. published the artcileSynthesis and antiproliferative activity of novel polynuclear heterocyclic compounds derived from 2,3-diaminophenazine, Application In Synthesis of 1076-59-1, the publication is European Journal of Medicinal Chemistry (2015), 568-576, database is CAplus and MEDLINE.
2,3-Diaminophenazine was used as a precursor for the preparation of novel phenazine derivatives such as imidazo[4,5-b]phenazine-2-thione and its derivatives All compounds were tested as inhibitors of the proliferation of human lung carcinoma and colorectal cancer cell lines through inhibition of tyrosine kinases. Most of compounds exert good activity against the two cancer cell lines. Five compounds were found to possess the same activity as the standard drug cisplatin. The synthesis of the target compounds was achieved using 2,3-phenazinediamine, 5,5-dimethyl-1,3-cyclohexanedione, 3-phenyl-5(4H)-isoxazolone, 2,4-dihydro-5-methyl-2-phenyl-3-pyrazol-3-one, 3-oxobutanoic acid Et ester, propanedioic acid, benzoic acid, ethanedioyl dichloride, 3,4-dichloro-2,5-furandione, 2-chloro-2-(2-phenylhydrazinylidene)acetic acid Et ester, benzaldehyde derivatives, etc., as starting materials. The title compounds thus formed included 2-(3-chlorophenyl)-1H-imidazo[4,5-b]phenazine, 1,3-dihydro-2H-imidazo[4,5-b]phenazine-2-thione, 1,4-dihydropyrazino[2,3-b]phenazine-2,3-dione, N,N‘-2,3-phenazinediylbis[benzamide].
European Journal of Medicinal Chemistry published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Application In Synthesis of 1076-59-1.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem