123770-62-7, Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 376 ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (50.0 mg, 0.29 mmol) in 311 DCM (2 mL) was added 378 diethylaminosulfur trifluoride (70.6 mg, 0.06 ml, 0.44 mmol). The mixture was stirred at 40 C. for 1 hour. 55 Water (3 mL) was added and the mixture was extracted with ethyl acetate (5 mL¡Á3). The combined organic layers were washed with brine (5 mL), dried over Na2SO4 and concentrated. The crude mixture was purified by flash chromatography with heptane:ethyl acetate=1:0 to 0:1 to give 379 ethyl 5-(fluoromethyl)isoxazole-3-carboxylate (41.0 mg).
123770-62-7, As the paragraph descriping shows that 123770-62-7 is playing an increasingly important role.
Reference£º
Patent; H. Lundbeck A/S; Juhl, Karsten; Jessing, Mikkel; Langgard, Morten; Vital, Paulo Jorge Vieira; Kehler, Jan; Rasmussen, Lars Kyhn; Clementson, Carl Martin Sebastian; Marigo, Mauro; (154 pag.)US2019/194189; (2019); A1;,
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