Spinks, Daniel published the artcileDesign, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors, COA of Formula: C8H5F3N4, the publication is ChemMedChem (2012), 7(1), 95-106, database is CAplus and MEDLINE.
Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis. It is one of only a handful of chem. validated targets for T. brucei in vivo. To identify novel inhibitors of TbTryS we screened our inhouse diverse compound library that contains 62,000 compounds This resulted in the identification of six novel hit series of TbTryS inhibitors. Herein we describe the SAR exploration of these hit series, which gave rise to one common series with potency against the enzyme target. Cellular studies on these inhibitors confirmed on-target activity, and the compounds have proven to be very useful tools for further study of the trypanothione pathway in kinetoplastids.
ChemMedChem published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C4H10O2, COA of Formula: C8H5F3N4.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem