With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
2-(2-(3,5-dimethylisoxazole-4-carbonyl)benzofuran-5-yl)-N-((2,4-dimethylphenyl)(phenyl)methyl) acetamidea) methyl 3,5-dimethylisoxazol -4-carboxylateTo a solution of 3,5-dimethylisoxazole-4-carboxylic acid (9.2 g, 65.2 mmol) in MeOH (50 mL) was added SOCI2 (15.3 g, 130.4 mmol) very slowly. The reaction mixture was heated to 70 C overnight. The reaction mixture was then cooled to rt, concentrated, and purified by column chromatography (10% EtO Ac/petroleum ether) to afford the title compound (9.0 g, 89%). LCMS- Pl : 156 [M+H]+; Rt: 1.404 min., 2510-36-3
As the paragraph descriping shows that 2510-36-3 is playing an increasingly important role.
Reference£º
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard; WO2013/19682; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem