36958-61-9, 5-(Bromomethyl)-3-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3-(4-Chlorophenyl)-N-isopropyl-N,4-dimethyl-1 -[(3-methyl-isoxazol-5-yl)-methyl]-5- (trifluoromethyl)-1 H-pyrrole-2-carboxylic acid amide (example 067)To the stirred solution of 3-(4-chlorophenyl)-N-isopropyl-N,4-dimethyl-5-(trifluoromethyl)-1 H-pyrrole-2- carboxamide (200mg, 0.581 mmol) in MeCN was added Cs2C03at 0C under N2atmosphere. The reaction mixture was stirred for 30 min at 0C then charged 5-(bromomethyl)-3-methylisoxazole (11 1 mg, 0.639mmol). The mixture was warmed to RT and refluxed for 12 h. It was then quenched into ice water (100ml_) and extracted with EtOAc (3x100mL). The combined organic layer was washed successively with water, brine, dried (Na2S04) and concentrated to dryness in vacuo. The residue was purified by flash column chromatography (silica gel; 60-120mesh) and the compound eluted with 20% EtOAc in petroleum ether to give 82mg (39%) of example 67 as pale yellow liquid. [TLC system: 30% EtOAc -petroleum ether; Rf= 0.31]
36958-61-9, 36958-61-9 5-(Bromomethyl)-3-methylisoxazole 10607354, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; GRUeNENTHAL GMBH; REICH, Melanie; SCHUNK, Stefan; JAKOB, Florian; STEINHAGEN, Henning; DAMANN, Nils; HAURAND, Michael; HAMLYN, Richard; ROGERS, Marc; SUTTON, Kathy; WO2015/90599; (2015); A1;,
Isoxazole – Wikipedia
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