Lin, Jin-bing published the artcileEffect of parecoxib sodium on intravenous analgesic effect of dezocine after cesarean section, Computed Properties of 198470-85-8, the publication is Guangdong Yixue (2017), 38(7), 1098-1100, database is CAplus.
Objective: To observe the effect of parecoxib sodium on the analgesic effect of dezocine after cesarean section and its adverse reactions. Methods: 80 patients with ASA I-II grades combined spinal-epidural anesthesia who underwent voluntary postoperative analgesia after cesarean section were divided into parecoxib sodium group (P group) and control group (C group) according to the random number table, 40 cases in each. After the fetus was delivered, group P received i.v. injection of parecoxib sodium 40 mg, and group C received i.v. injection of the same amount of normal saline. After the operation, self-controlled i.v. analgesia with dezocine was used, and the analgesic solution was dezocine 0.5 mg /kg + normal saline to 100 mL. Adopt LCP mode of administration was used: loading dose (dezocine 5 mg) + maintenance dose 2.0 mL/h + single PCA dose 1 mL, lock-in time 15 min. The visual analog (VAS) pain scores at 2, 4, 8, 12, and 24 h after the operation of the parturient were recorded. The degree of uterine contraction pain within 24 h after the operation was recorded, and the satisfaction of the parturient鈥瞫 analgesia and overall adverse reaction rate were compared. Results: The VAS scores of the incision at 8 and 12 h in the P group were significantly lower than those in the C group (P < 0.05). The degree of postoperative uterine contraction pain in group P was significantly lower than that in group C (P < 0.05). The overall satisfaction of analgesia in group P was significantly higher than that in group C (P < 0.05). There was no significant difference in the incidence of overall adverse reactions between the two groups (P > 0.05). Conclusion: Parecoxib sodium can enhance the effect of dezocine for i.v. patient-controlled analgesia after cesarean section, reduce the degree of uterine contraction pain, and improve women鈥瞫 satisfaction without increasing adverse reactions.
Guangdong Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Computed Properties of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem