Kusumi, Takenori et al. published their research in Tetrahedron Letters in 1981 | CAS: 80348-66-9

Isoxazol-4-ol (cas: 80348-66-9) belongs to isoxazole derivatives. An isoxazolyl group is found in many beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. Isoxazole can be synthesised via a variety of methods. Examples include via a 1,3-dipolar cycloaddition of nitrile oxides with alkynes.Application In Synthesis of Isoxazol-4-ol

Isolation, structure, and synthesis of 4-hydroxyisoxazole (triumferol), a seed germination inhibitor from an African plant was written by Kusumi, Takenori;Chang, Conway C.;Wheeler, Margaret;Kubo, Isao;Nakanishi, Koji;Naoki, Hideo. And the article was included in Tetrahedron Letters in 1981.Application In Synthesis of Isoxazol-4-ol The following contents are mentioned in the article:

Triumferol (I; R = OH) (II) was isolated from Triumfetta rhomboidea, and its structure was determined by standard spectral methods. II had antigermination activity against lettuce seeds (100% at 100 ppm, 70% at 50 ppm). II was prepared from I (R = CO2H) by sequential chlorination (PCl5), Grignard reaction with MeBr, and oxidative cleavage (H2O2, H2SO4, CH2Cl2, reflux). This study involved multiple reactions and reactants, such as Isoxazol-4-ol (cas: 80348-66-9Application In Synthesis of Isoxazol-4-ol).

Isoxazol-4-ol (cas: 80348-66-9) belongs to isoxazole derivatives. An isoxazolyl group is found in many beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. Isoxazole can be synthesised via a variety of methods. Examples include via a 1,3-dipolar cycloaddition of nitrile oxides with alkynes.Application In Synthesis of Isoxazol-4-ol

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem