With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4
General procedure: Acyl chloride (1.1 equiv) was added to a suspension of 5(1.0 equiv) and potassium carbonate (10 equiv) in THF at roomtemperature under nitrogen. After 2 h, the reaction was quenchedby the addition of H2O and the resulting mixture was extractedwith EtOAc. The organic layer was dried over MgSO4, filtered,and concentrated under reduced pressure. The residue was purifiedby column chromatography to provide the desired products6a-6q.
As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.
Reference£º
Article; Chu, Kuang-Feng; Yao, Chun-Hsu; Song, Jen-Shin; Chen, Chiung-Tong; Yeh, Teng-Kuang; Hsieh, Tsung-Chih; Huang, Chung-Yu; Wang, Min-Hsien; Wu, Szu-Huei; Chang, Wei-En; Chao, Yu-Sheng; Lee, Jinq-Chyi; Bioorganic and Medicinal Chemistry; vol. 24; 10; (2016); p. 2242 – 2250;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem